Mediation analysis reveals common mechanisms of RUNX1 point mutations and RUNX1/RUNX1T1 fusions influencing survival of patients with acute myeloid leukemia

Alterations of RUNX1 in acute myeloid leukemia (AML) are associated with either a more favorable outcome in the case of the RUNX1/RUNX1T1 fusion or unfavorable prognosis in the case of point mutations. In this project we aimed to identify genes responsible for the observed differences in outcome tha...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Hornung, Roman, Jurinovic, Vindi, Batcha, Aarif M. N., Bamopoulos, Stefanos A., Rothenberg-Thurley, Maja, Amler, Susanne, Sauerland, Maria Cristina, Berdel, Wolfgang E., Wörmann, Bernhard J., Bohlander, Stefan K., Braess, Jan, Hiddemann, Wolfgang, Lehmann, Sören, Mareschal, Sylvain, Spiekermann, Karsten, Metzeler, Klaus H., Herold, Tobias, Boulesteix, Anne-Laure
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062501/
https://ncbi.nlm.nih.gov/pubmed/30050054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29593-2
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