Allelic Imbalance of Recurrently Mutated Genes in Acute Myeloid Leukaemia

The patho-mechanism of somatic driver mutations in cancer usually involves transcription, but the proportion of mutations and wild-type alleles transcribed from DNA to RNA is largely unknown. We systematically compared the variant allele frequencies of recurrently mutated genes in DNA and RNA sequen...

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Publicat a:Sci Rep
Autors principals: Batcha, Aarif M. N., Bamopoulos, Stefanos A., Kerbs, Paul, Kumar, Ashwini, Jurinovic, Vindi, Rothenberg-Thurley, Maja, Ksienzyk, Bianka, Philippou-Massier, Julia, Krebs, Stefan, Blum, Helmut, Schneider, Stephanie, Konstandin, Nikola, Bohlander, Stefan K., Heckman, Caroline, Kontro, Mika, Hiddemann, Wolfgang, Spiekermann, Karsten, Braess, Jan, Metzeler, Klaus H., Greif, Philipp A., Mansmann, Ulrich, Herold, Tobias
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692371/
https://ncbi.nlm.nih.gov/pubmed/31409822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48167-4
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