Thymic tuft cells promote an IL4-enriched medulla and shape thymocyte development

The thymus is responsible for generating a diverse yet self-tolerant T cell pool (1). While the thymic medulla is largely composed of developing and mature AIRE(+) epithelial cells, recent evidence suggests far greater heterogeneity amongst medullary thymic epithelial cells than previously appreciat...

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Bibliographic Details
Published in:Nature
Main Authors: Miller, Corey N., Proekt, Irina, von Moltke, Jakob, Wells, Kristen L., Rajpurkar, Aparna R., Wang, Haiguang, Rattay, Kristin, Khan, Imran S., Metzger, Todd C., Pollack, Joshua L., Fries, Adam C., Lwin, Wint W., Wigton, Eric J., Parent, Audrey V., Kyewski, Bruno, Erle, David J., Hogquist, Kristin A., Steinmetz, Lars M., Locksley, Richard M., Anderson, Mark S.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062473/
https://ncbi.nlm.nih.gov/pubmed/30022164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0345-2
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