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Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla

The thymic medulla is generally held to be a specialized environment for negative selection. However, many self-reactive thymocytes first encounter ubiquitous self-antigens in the cortex. Cortical epithelial cells are vital for positive selection, but whether such cells can also promote negative sel...

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Detalhes bibliográficos
Main Authors: McCaughtry, Tom M., Baldwin, Troy A., Wilken, Matthew S., Hogquist, Kristin A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2571932/
https://ncbi.nlm.nih.gov/pubmed/18936237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080866
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