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Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
The thymic medulla is generally held to be a specialized environment for negative selection. However, many self-reactive thymocytes first encounter ubiquitous self-antigens in the cortex. Cortical epithelial cells are vital for positive selection, but whether such cells can also promote negative sel...
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| Asıl Yazarlar: | , , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The Rockefeller University Press
2008
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2571932/ https://ncbi.nlm.nih.gov/pubmed/18936237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080866 |
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