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Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
The thymic medulla is generally held to be a specialized environment for negative selection. However, many self-reactive thymocytes first encounter ubiquitous self-antigens in the cortex. Cortical epithelial cells are vital for positive selection, but whether such cells can also promote negative sel...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2571932/ https://ncbi.nlm.nih.gov/pubmed/18936237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080866 |
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