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Positive and negative selection of the T cell repertoire: what thymocytes see and don't see

The fate of developing T cells is specified by interactions of their antigen receptor with self-peptide/MHC complexes displayed by thymic antigen presenting cells (APCs). Various thymic APCs subsets are strategically positioned in particular thymic microenvironments and orchestrate the selection of...

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Detalhes bibliográficos
Publicado no:Nat Rev Immunol
Main Authors: Klein, Ludger, Kyewski, Bruno, Allen, Paul M., Hogquist, Kristin A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757912/
https://ncbi.nlm.nih.gov/pubmed/24830344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nri3667
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