Učitavanje...
Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1
Niemann-Pick C1 (NPC1) is a polytopic membrane protein with 13 transmembrane helices that exports LDL-derived cholesterol from lysosomes by carrying it through the 80 Å glycocalyx and the 40 Å lipid bilayer. Transport begins when cholesterol binds to the N-terminal domain (NTD) of NPC1, which projec...
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| Izdano u: | eLife |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
eLife Sciences Publications, Ltd
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6062155/ https://ncbi.nlm.nih.gov/pubmed/30047864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38564 |
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