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Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid

Hepatic NADPH-cytochrome P450 oxidoreductase null (HRN™) mice exhibit no functional expression of hepatic cytochrome P450 (P450) when compared to wild type (WT) mice, but have normal hepatic and extrahepatic expression of other biotransformation enzymes. We have assessed the utility of HRN™ mice for...

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Publicat a:Toxicol Res (Camb)
Autors principals: Akingbasote, James A., Foster, Alison J., Jones, Huw B., David, Rhiannon, Gooderham, Nigel J., Wilson, Ian D., Kenna, J. Gerry
Format: Artigo
Idioma:Inglês
Publicat: Royal Society of Chemistry 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062145/
https://ncbi.nlm.nih.gov/pubmed/30090479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6tx00376a
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