Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid

Hepatic NADPH-cytochrome P450 oxidoreductase null (HRN™) mice exhibit no functional expression of hepatic cytochrome P450 (P450) when compared to wild type (WT) mice, but have normal hepatic and extrahepatic expression of other biotransformation enzymes. We have assessed the utility of HRN™ mice for...

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Detalhes bibliográficos
Publicado no:Toxicol Res (Camb)
Main Authors: Akingbasote, James A., Foster, Alison J., Jones, Huw B., David, Rhiannon, Gooderham, Nigel J., Wilson, Ian D., Kenna, J. Gerry
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062145/
https://ncbi.nlm.nih.gov/pubmed/30090479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6tx00376a
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