Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription

Natural and lab-evolved proteins often recognize their RNA partners with exquisite affinity. Structural analysis of such complexes can offer valuable insight into sequence-selective recognition that can be exploited to alter biological function. Here, we describe the structure of a lab-evolved RNA r...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Belashov, Ivan A, Crawford, David W, Cavender, Chapin E, Dai, Peng, Beardslee, Patrick C, Mathews, David H, Pentelute, Bradley L, McNaughton, Brian R, Wedekind, Joseph E
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
NAR Breakthrough Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061845/
https://ncbi.nlm.nih.gov/pubmed/29961805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky529
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