Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors

RNA-protein interfaces control key replication events during the HIV-1 life cycle. The viral trans-activator of transcription (Tat) protein uses an archetypal arginine-rich motif (ARM) to recruit the host positive transcription elongation factor b (pTEFb) complex onto the viral trans-activation resp...

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Publicado en:J Biol Chem
Main Authors: Chavali, Sai Shashank, Mali, Sachitanand M., Jenkins, Jermaine L., Fasan, Rudi, Wedekind, Joseph E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864049/
https://ncbi.nlm.nih.gov/pubmed/33051202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015444
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