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A toxic imbalance of Hsp70s in Saccharomyces cerevisiae is caused by competition for cofactors

Molecular chaperones are responsible for managing protein folding from translation through degradation. These crucial machines ensure that protein homeostasis is optimally maintained for cell health. However, “too much of a good thing” can be deadly, and the excess of chaperones can be toxic under c...

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Dettagli Bibliografici
Pubblicato in:Mol Microbiol
Autori principali: Keefer, Kathryn M., True, Heather L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054465/
https://ncbi.nlm.nih.gov/pubmed/28665048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13741
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