Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation

BACKGROUND: Histone deacetylase inhibitors (HDACi) suppress cytokine production in immune and stromal cells of patients with rheumatoid arthritis (RA). Here, we investigated the effects of the HDACi givinostat (ITF2357) on the transcriptional and post-transcriptional regulation of inflammatory marke...

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Detaylı Bibliyografya
Yayımlandı:Arthritis Res Ther
Asıl Yazarlar: Angiolilli, Chiara, Kabala, Pawel A., Grabiec, Aleksander M., Rossato, Marzia, Lai, Wi S., Fossati, Gianluca, Mascagni, Paolo, Steinkühler, Christian, Blackshear, Perry J., Reedquist, Kris A., Baeten, Dominique L., Radstake, Timothy R. D. J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053802/
https://ncbi.nlm.nih.gov/pubmed/30029685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1638-4
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