Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation

BACKGROUND: Histone deacetylase inhibitors (HDACi) suppress cytokine production in immune and stromal cells of patients with rheumatoid arthritis (RA). Here, we investigated the effects of the HDACi givinostat (ITF2357) on the transcriptional and post-transcriptional regulation of inflammatory marke...

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Publicado en:Arthritis Res Ther
Main Authors: Angiolilli, Chiara, Kabala, Pawel A., Grabiec, Aleksander M., Rossato, Marzia, Lai, Wi S., Fossati, Gianluca, Mascagni, Paolo, Steinkühler, Christian, Blackshear, Perry J., Reedquist, Kris A., Baeten, Dominique L., Radstake, Timothy R. D. J.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2018
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053802/
https://ncbi.nlm.nih.gov/pubmed/30029685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1638-4
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