Lifelong reduction in complex IV induces tissue‐specific metabolic effects but does not reduce lifespan or healthspan in mice

Loss of SURF1, a Complex IV assembly protein, was reported to increase lifespan in mice despite dramatically lower cytochrome oxidase (COX) activity. Consistent with this, our previous studies found advantageous changes in metabolism (reduced adiposity, increased insulin sensitivity, and mitochondri...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Deepa, Sathyaseelan S., Pharaoh, Gavin, Kinter, Michael, Diaz, Vivian, Fok, Wilson C., Riddle, Kaitlyn, Pulliam, Daniel, Hill, Shauna, Fischer, Kathleen E., Soto, Vanessa, Georgescu, Constantin, Wren, Jonathan D., Viscomi, Carlo, Richardson, Arlan, Van Remmen, Holly
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052393/
https://ncbi.nlm.nih.gov/pubmed/29696791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12769
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