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Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K(+) currents in cardiomyocytes and prolongs cardiac action potential duration
SMO (Smoothened), the central transducer of Hedgehog signaling, is coupled to heterotrimeric G(i) proteins in many cell types, including cardiomyocytes. In this study, we report that activation of SMO with SHH (Sonic Hedgehog) or a small agonist, purmorphamine, rapidly causes a prolongation of the a...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6052211/ https://ncbi.nlm.nih.gov/pubmed/29802197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001989 |
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