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Determinants of Human Glucokinase Activation and Implications for Small Molecule Allosteric Control
Glucokinase (GK) is an enzyme that catalyzes the ATP-dependent phosphorylation of glucose to form glucose-6-phosphate, and it is a tightly regulated checkpoint in glucose homeostasis. GK is known to undergo substantial conformational changes upon glucose binding. The monomeric enzyme possesses a hig...
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| Izdano u: | Biochim Biophys Acta |
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| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6051901/ https://ncbi.nlm.nih.gov/pubmed/29885360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2018.06.001 |
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