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Allosteric Tuning of Caspase‐7: A Fragment‐Based Drug Discovery Approach
The caspase family of cysteine proteases are highly sought‐after drug targets owing to their essential roles in apoptosis, proliferation, and inflammation pathways. High‐throughput screening efforts to discover inhibitors have gained little traction. Fragment‐based screening has emerged as a powerfu...
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| 出版年: | Angew Chem Int Ed Engl |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5698726/ https://ncbi.nlm.nih.gov/pubmed/28940929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201706959 |
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