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Allosteric Tuning of Caspase‐7: A Fragment‐Based Drug Discovery Approach
The caspase family of cysteine proteases are highly sought‐after drug targets owing to their essential roles in apoptosis, proliferation, and inflammation pathways. High‐throughput screening efforts to discover inhibitors have gained little traction. Fragment‐based screening has emerged as a powerfu...
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| Veröffentlicht in: | Angew Chem Int Ed Engl |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5698726/ https://ncbi.nlm.nih.gov/pubmed/28940929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201706959 |
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