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Small-Molecule Allosteric Activation of Human Glucokinase in the Absence of Glucose

[Image: see text] Synthetic allosteric activators of human glucokinase are receiving considerable attention as potential diabetes therapeutic agents. Although their mechanism of action is not fully understood, structural studies suggest that activator association requires prior formation of a binary...

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Main Authors: Bowler, Joseph M., Hervert, Katherine L., Kearley, Mark L., Miller, Brian G.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2013
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840467/
https://ncbi.nlm.nih.gov/pubmed/24294411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400061x
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