MUTATIONAL ANALYSIS OF ALLOSTERIC ACTIVATION AND INHIBITION OF GLUCOKINASE

Glucokinase (GK) is activated by glucose binding to the substrate site, is inhibited by GK regulatory protein (GKRP) but stimulated by GK activator drugs (GKAs). To further explore the mechanisms of these processes we studied pure recombinant human GK (normal enzyme and a selection of 31 mutants) us...

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Detalhes bibliográficos
Main Authors: Zelent, Bogumil, Odili, Stella, Buettger, Carol, Zelent, Dorothy K., Chen, Pan, Fenner, Deborah, Bass, Joseph, Stanley, Charles, Laberge, Monique, Vanderkooi, Jane M., Sarabu, Ramakanth, Grimsby, Joseph, Matschinsky, Franz M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005413/
https://ncbi.nlm.nih.gov/pubmed/21831042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110440
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