MUTATIONAL ANALYSIS OF ALLOSTERIC ACTIVATION AND INHIBITION OF GLUCOKINASE

Glucokinase (GK) is activated by glucose binding to the substrate site, is inhibited by GK regulatory protein (GKRP) but stimulated by GK activator drugs (GKAs). To further explore the mechanisms of these processes we studied pure recombinant human GK (normal enzyme and a selection of 31 mutants) us...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Zelent, Bogumil, Odili, Stella, Buettger, Carol, Zelent, Dorothy K., Chen, Pan, Fenner, Deborah, Bass, Joseph, Stanley, Charles, Laberge, Monique, Vanderkooi, Jane M., Sarabu, Ramakanth, Grimsby, Joseph, Matschinsky, Franz M.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2011
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005413/
https://ncbi.nlm.nih.gov/pubmed/21831042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110440
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