Generation of N-Ethyl-N-nitrosourea (ENU) Diabetes Models in Mice Demonstrates Genotype-specific Action of Glucokinase Activators

We performed genome-wide mutagenesis in C57BL/6J mice using N-ethyl-N-nitrosourea to identify mutations causing high blood glucose early in life and to produce new animal models of diabetes. Of a total of 13 new lines confirmed by heritability testing, we identified two semi-dominant pedigrees with...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Fenner, Deborah, Odili, Stella, Hong, Hee-Kyung, Kobayashi, Yumiko, Kohsaka, Akira, Siepka, Sandra M., Vitaterna, Martha H., Chen, Pan, Zelent, Bogumil, Grimsby, Joseph, Takahashi, Joseph S., Matschinsky, Franz M., Bass, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234779/
https://ncbi.nlm.nih.gov/pubmed/21921030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.269100
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados