Generation of N-Ethyl-N-nitrosourea (ENU) Diabetes Models in Mice Demonstrates Genotype-specific Action of Glucokinase Activators

We performed genome-wide mutagenesis in C57BL/6J mice using N-ethyl-N-nitrosourea to identify mutations causing high blood glucose early in life and to produce new animal models of diabetes. Of a total of 13 new lines confirmed by heritability testing, we identified two semi-dominant pedigrees with...

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Autors principals: Fenner, Deborah, Odili, Stella, Hong, Hee-Kyung, Kobayashi, Yumiko, Kohsaka, Akira, Siepka, Sandra M., Vitaterna, Martha H., Chen, Pan, Zelent, Bogumil, Grimsby, Joseph, Takahashi, Joseph S., Matschinsky, Franz M., Bass, Joseph
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234779/
https://ncbi.nlm.nih.gov/pubmed/21921030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.269100
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