The Value of Activated Ion Electron Transfer Dissociation for High-Throughput Top-Down Characterization of Intact Proteins

High-throughput top-down proteomic experiments directly identify proteoforms in complex mixtures, making high quality tandem mass spectra necessary to deeply characterize proteins with many sources of variation. Collision-based dissociation methods offer expedient data acquisition, but often fail to...

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Udgivet i:Anal Chem
Main Authors: Riley, Nicholas M., Sikora, Jacek W., Seckler, Henrique S., Greer, Joseph B., Fellers, Ryan T., LeDuc, Richard D., Westphall, Michael S., Thomas, Paul M., Kelleher, Neil L., Coon, Joshua J.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050102/
https://ncbi.nlm.nih.gov/pubmed/29924586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.8b01638
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