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The C-Score: A Bayesian Framework to Sharply Improve Proteoform Scoring in High-Throughput Top Down Proteomics

[Image: see text] The automated processing of data generated by top down proteomics would benefit from improved scoring for protein identification and characterization of highly related protein forms (proteoforms). Here we propose the “C-score” (short for Characterization Score), a Bayesian approach...

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Detalhes bibliográficos
Main Authors: LeDuc, Richard D., Fellers, Ryan T., Early, Bryan P., Greer, Joseph B., Thomas, Paul M., Kelleher, Neil L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084843/
https://ncbi.nlm.nih.gov/pubmed/24922115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr401277r
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