MGMT inhibition in ER positive breast cancer leads to CDC2, TOP2A, AURKB, CDC20, KIF20A, Cyclin A2, Cyclin B2, Cyclin D1, ERα and Survivin inhibition and enhances response to temozolomide

The DNA damage repair enzyme, O(6)-methylguanine DNA methyltransferase (MGMT) is overexpressed in breast cancer, correlating directly with estrogen receptor (ER) expression and function. In ER negative breast cancer the MGMT promoter is frequently methylated. In ER positive breast cancer MGMT is upr...

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Detalles Bibliográficos
Publicado en:Oncotarget
Autores principales: Bobustuc, George C., Kassam, Amin B., Rovin, Richard A., Jeudy, Sheila, Smith, Joshua S., Isley, Beth, Singh, Maharaj, Paranjpe, Ameya, Srivenugopal, Kalkunte S., Konduri, Santhi D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6049872/
https://ncbi.nlm.nih.gov/pubmed/30038716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25696
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