MGMT inhibition in ER positive breast cancer leads to CDC2, TOP2A, AURKB, CDC20, KIF20A, Cyclin A2, Cyclin B2, Cyclin D1, ERα and Survivin inhibition and enhances response to temozolomide

Ítems similars

• MGMT Inhibition Restores ERα Functional Sensitivity to Antiestrogen Therapy
  per: Bobustuc, George C, et al.
  Publicat: (2012)
• Degradation of NF-κB, p53 and other regulatory redox-sensitive proteins by thiol-conjugating and -nitrosylating drugs in human tumor cells
  per: Paranjpe, Ameya, et al.
  Publicat: (2013)
• EXTH-24. MGMT INHIBITION BY DISULFIRAM/COPPER COMPLEX RESTORES VELIPARIB ENHANCING TEMOZOLOMIDE EFFECT IN UNFAVORABLE GLIOBLASTOMA MULTIFORME
  per: Bobustuc, George, et al.
  Publicat: (2017)
• New insights into estrogenic regulation of O(6)-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O(6)-benzylguanine indicates fresh avenues for therapy
  per: Paranjpe, Ameya, et al.
  Publicat: (2016)
• Disulfiram is a direct and potent inhibitor of human O(6)-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage
  per: Paranjpe, Ameya, et al.
  Publicat: (2014)