MGMT inhibition in ER positive breast cancer leads to CDC2, TOP2A, AURKB, CDC20, KIF20A, Cyclin A2, Cyclin B2, Cyclin D1, ERα and Survivin inhibition and enhances response to temozolomide

The DNA damage repair enzyme, O(6)-methylguanine DNA methyltransferase (MGMT) is overexpressed in breast cancer, correlating directly with estrogen receptor (ER) expression and function. In ER negative breast cancer the MGMT promoter is frequently methylated. In ER positive breast cancer MGMT is upr...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bobustuc, George C., Kassam, Amin B., Rovin, Richard A., Jeudy, Sheila, Smith, Joshua S., Isley, Beth, Singh, Maharaj, Paranjpe, Ameya, Srivenugopal, Kalkunte S., Konduri, Santhi D.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6049872/
https://ncbi.nlm.nih.gov/pubmed/30038716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25696
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