New insights into estrogenic regulation of O(6)-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O(6)-benzylguanine indicates fresh avenues for therapy

Endocrine therapy using estrogen receptor-α (ER-α) antagonists for attenuating horm2one-driven cell proliferation is a major treatment modality for breast cancers. To exploit any DNA repair deficiencies associated with endocrine therapy, we investigated the functional and physical interactions of ER...

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Detalhes bibliográficos
Publicado no:J Biomed Res
Main Authors: Paranjpe, Ameya, Bailey, Nathan I., Konduri, Santhi, Bobustuc, George C., Ali-Osman, Francis, Yusuf, Mohd. A., Punganuru, Surendra R., Madala, Hanumantha Rao, Basak, Debasish, Mostofa, AGM, Srivenugopal, Kalkunte S.
Formato: Artigo
Idioma:Inglês
Publicado em: Editorial Department of Journal of Biomedical Research 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5044712/
https://ncbi.nlm.nih.gov/pubmed/27845303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7555/JBR.30.20160040
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