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S-phase Specific Downregulation of Human O(6)-Methylguanine DNA Methyltransferase (MGMT) and its Serendipitous Interactions with PCNA and p21(cip1) Proteins in Glioma Cells
Whether the antimutagenic DNA repair protein MGMT works solo in human cells and if it has other cellular functions is not known. Here, we show that human MGMT associates with PCNA and in turn, with the cell cycle inhibitor, p21(cip1) in glioblastoma and other cancer cell lines. MGMT protein was show...
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| Publicado no: | Neoplasia |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Neoplasia Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5909491/ https://ncbi.nlm.nih.gov/pubmed/29510343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2018.01.010 |
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