S-phase Specific Downregulation of Human O(6)-Methylguanine DNA Methyltransferase (MGMT) and its Serendipitous Interactions with PCNA and p21(cip1) Proteins in Glioma Cells

Whether the antimutagenic DNA repair protein MGMT works solo in human cells and if it has other cellular functions is not known. Here, we show that human MGMT associates with PCNA and in turn, with the cell cycle inhibitor, p21(cip1) in glioblastoma and other cancer cell lines. MGMT protein was show...

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Vydáno v:Neoplasia
Hlavní autoři: Mostofa, AGM, Punganuru, Surendra R., Madala, Hanumantha Rao, Srivenugopal, Kalkunte S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press 2018
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Original article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909491/
https://ncbi.nlm.nih.gov/pubmed/29510343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2018.01.010
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