Brain- and brain tumor-penetrating disulfiram nanoparticles: Sequence of cytotoxic events and efficacy in human glioma cell lines and intracranial xenografts

There is great interest in repurposing disulfiram (DSF), a rapidly metabolizing nontoxic drug, for brain cancers and other cancers. To overcome the instability and low therapeutic efficacy, we engineered passively-targeted DSF-nanoparticles (DSFNPs) using biodegradable monomethoxy (polyethylene glyc...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Madala, Hanumantha Rao, Punganuru, Surendra R., Ali-Osman, Francis, Zhang, Ruiwen, Srivenugopal, Kalkunte S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790476/
https://ncbi.nlm.nih.gov/pubmed/29423059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23320
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