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EXTH-36. DEVELOPMENT OF STABLE AND BRAIN-PENETRATING DISULFIRAM NANOPARTICLES, CHARACTERIZATION AND EFFICACY IN GLIOMA CELL CULTURE AND XENOGRAFT MODELS
Blood brain-barrier entry, tumor heterogeneity, need to eliminate the tumorigenic stem cells and inhibit the DNA repair protein MGMT are all essential considerations in glioma treatment. Previously, we showed that alcohol aversion drug disulfiram (DSF) shares all these properties [Carcinogenesis 35,...
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| Gepubliceerd in: | Neuro Oncol |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692037/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.328 |
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