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Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils
The formation and spreading of amyloid aggregates from the presynaptic protein α-synuclein in the brain play central roles in the pathogenesis of Parkinson’s disease. Here, we use high-resolution atomic force microscopy to investigate the early oligomerization events of α-synuclein with single monom...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6048494/ https://ncbi.nlm.nih.gov/pubmed/29941606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721220115 |
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