Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils

The formation and spreading of amyloid aggregates from the presynaptic protein α-synuclein in the brain play central roles in the pathogenesis of Parkinson’s disease. Here, we use high-resolution atomic force microscopy to investigate the early oligomerization events of α-synuclein with single monom...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Ruggeri, Francesco Simone, Benedetti, Fabrizio, Knowles, Tuomas P. J., Lashuel, Hilal A., Sekatskii, Sergey, Dietler, Giovanni
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2018
Ábhair:
Physical Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048494/
https://ncbi.nlm.nih.gov/pubmed/29941606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721220115
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