Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation

Macrophages are key immune cells for the initiation and development of atherosclerotic lesions. However, the macrophage regulatory nodes that determine how lesions progress in response to dietary challenges are not fully understood. Liver X receptors (LXRs) are sterol-regulated transcription factors...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Gage, M. C., Bécares, N., Louie, R., Waddington, K. E., Zhang, Y., Tittanegro, T. H., Rodríguez-Lorenzo, S., Jathanna, A., Pourcet, B., Pello, O. M., De la Rosa, J. V., Castrillo, A., Pineda-Torra, I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048484/
https://ncbi.nlm.nih.gov/pubmed/29950315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721245115
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