Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation

Macrophages are key immune cells for the initiation and development of atherosclerotic lesions. However, the macrophage regulatory nodes that determine how lesions progress in response to dietary challenges are not fully understood. Liver X receptors (LXRs) are sterol-regulated transcription factors...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Gage, M. C., Bécares, N., Louie, R., Waddington, K. E., Zhang, Y., Tittanegro, T. H., Rodríguez-Lorenzo, S., Jathanna, A., Pourcet, B., Pello, O. M., De la Rosa, J. V., Castrillo, A., Pineda-Torra, I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048484/
https://ncbi.nlm.nih.gov/pubmed/29950315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721245115
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