Frequency, impact and a preclinical study of novel ERBB gene family mutations in HER2-positive breast cancer

BACKGROUND: Somatic mutations in the ERBB genes (epidermal growth factor receptor: EGFR, ERBB2, ERBB3, ERBB4) promote oncogenesis and lapatinib resistance in metastatic HER2+ (human epidermal growth factor-like receptor 2) breast cancer in vitro. Our study aimed to determine the frequency of mutatio...

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Dades bibliogràfiques
Publicat a:Ther Adv Med Oncol
Autors principals: Elster, Naomi, Toomey, Sinead, Fan, Yue, Cremona, Mattia, Morgan, Clare, Weiner Gorzel, Karolina, Bhreathnach, Una, Milewska, Malgorzata, Murphy, Madeline, Madden, Stephen, Naidoo, Jarushka, Fay, Joanna, Kay, Elaine, Carr, Aoife, Kennedy, Sean, Furney, Simon, Mezynski, Janusz, Breathhnach, Oscar, Morris, Patrick, Grogan, Liam, Hill, Arnold, Kennedy, Susan, Crown, John, Gallagher, William, Hennessy, Bryan, Eustace, Alex
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2018
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047239/
https://ncbi.nlm.nih.gov/pubmed/30023006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758835918778297
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