A preclinical evaluation of the MEK inhibitor refametinib in HER2-positive breast cancer cell lines including those with acquired resistance to trastuzumab or lapatinib

PURPOSE: The MEK/MAPK pathway is commonly activated in HER2-positive breast cancer, but little investigation of targeting this pathway has been undertaken. Here we present the results of an in vitro preclinical evaluation of refametinib, an allosteric MEK1/2 inhibitor, in HER2-positive breast cancer...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: O’Shea, John, Cremona, Mattia, Morgan, Clare, Milewska, Malgorzata, Holmes, Frankie, Espina, Virginia, Liotta, Lance, O’Shaughnessy, Joyce, Toomey, Sinead, Madden, Stephen F., Carr, Aoife, Elster, Naomi, Hennessy, Bryan T., Eustace, Alex J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689598/
https://ncbi.nlm.nih.gov/pubmed/29156708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19461
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