Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants

[Image: see text] A series of linear HCV NS3/4A protease inhibitors was designed by eliminating the P2–P4 macrocyclic linker in grazoprevir, which, in addition to conferring conformational flexibility, allowed structure–activity relationship (SAR) exploration of diverse quinoxalines at the P2 positi...

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Gepubliceerd in:ACS Med Chem Lett
Hoofdauteurs: Rusere, Linah N., Matthew, Ashley N., Lockbaum, Gordon J., Jahangir, Muhammad, Newton, Alicia, Petropoulos, Christos J., Huang, Wei, Kurt Yilmaz, Nese, Schiffer, Celia A., Ali, Akbar
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2018
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047049/
https://ncbi.nlm.nih.gov/pubmed/30034602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00150
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