Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants

[Image: see text] A series of linear HCV NS3/4A protease inhibitors was designed by eliminating the P2–P4 macrocyclic linker in grazoprevir, which, in addition to conferring conformational flexibility, allowed structure–activity relationship (SAR) exploration of diverse quinoxalines at the P2 positi...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Rusere, Linah N., Matthew, Ashley N., Lockbaum, Gordon J., Jahangir, Muhammad, Newton, Alicia, Petropoulos, Christos J., Huang, Wei, Kurt Yilmaz, Nese, Schiffer, Celia A., Ali, Akbar
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047049/
https://ncbi.nlm.nih.gov/pubmed/30034602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00150
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