Caffeine Sensitizes U87-MG Human Glioblastoma Cells to Temozolomide through Mitotic Catastrophe by Impeding G2 Arrest

Temozolomide (TMZ) is the first-line chemotherapeutic agent in the treatment of glioblastoma multiforme (GBM). Despite its cytotoxic effect, TMZ also induces cell cycle arrest that may lead to the development of chemoresistance and eventual tumor recurrence. Caffeine, a widely consumed neurostimulan...

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Bibliografiske detaljer
Udgivet i:Biomed Res Int
Main Authors: Li, Ning, Zhang, Pingde, Kiang, Karrie Mei Yee, Cheng, Yin Stephen, Leung, Gilberto Ka Kit
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046144/
https://ncbi.nlm.nih.gov/pubmed/30050935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/5364973
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