Resveratrol abrogates the Temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the Temozolomide-induced senescence in glioma cells

BACKGROUND: Temozolomide (TMZ) is the most widely used drug to treat glioblastoma (GBM), which is the most common and aggressive primary tumor of the Central Nervous System and one of the hardest challenges in oncotherapy. TMZ is an alkylating agent that induces autophagy, apoptosis and senescence i...

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Autors principals: Filippi-Chiela, Eduardo C, Thomé, Marcos Paulo, Bueno e Silva, Mardja Manssur, Pelegrini, Alessandra Luíza, Ledur, Pitia Flores, Garicochea, Bernardo, Zamin, Lauren L, Lenz, Guido
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635906/
https://ncbi.nlm.nih.gov/pubmed/23522185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-147
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