Resveratrol abrogates the Temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the Temozolomide-induced senescence in glioma cells

BACKGROUND: Temozolomide (TMZ) is the most widely used drug to treat glioblastoma (GBM), which is the most common and aggressive primary tumor of the Central Nervous System and one of the hardest challenges in oncotherapy. TMZ is an alkylating agent that induces autophagy, apoptosis and senescence i...

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Detalhes bibliográficos
Main Authors: Filippi-Chiela, Eduardo C, Thomé, Marcos Paulo, Bueno e Silva, Mardja Manssur, Pelegrini, Alessandra Luíza, Ledur, Pitia Flores, Garicochea, Bernardo, Zamin, Lauren L, Lenz, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635906/
https://ncbi.nlm.nih.gov/pubmed/23522185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-147
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