Quinacrine enhances temozolomide cytotoxicity in temozolomide-sensitive and -resistant glioblastoma cells

Background: The alkylating agent temozolomide (TMZ) is widely used in glioblastoma multiforme (GBM) therapy. Unfortunately, TMZ-resistance frequently occurs in recurrent GBM and is the major cause of treatment failure. The anti-malarial drug quinacrine (QC) harbors antitumor and chemosensitivity pro...

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Detalhes bibliográficos
Main Authors: Pingde Zhang, Ning Li, Karrie Mei Yee Kiang, Zhiyuan Zhu, Gloria Wai Man Leung, Stephen Yin Cheng, Gilberto Ka Kit Leung
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer Medknow Publications 2018-01-01
Colecção:Glioma
Assuntos:
Apoptosis
autophagy
glioblastoma multiforme
quinacrine
temozolomide
Acesso em linha:http://www.jglioma.com/article.asp?issn=2589-6113;year=2018;volume=1;issue=5;spage=175;epage=181;aulast=Zhang
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