Caffeine Sensitizes U87-MG Human Glioblastoma Cells to Temozolomide through Mitotic Catastrophe by Impeding G2 Arrest

Temozolomide (TMZ) is the first-line chemotherapeutic agent in the treatment of glioblastoma multiforme (GBM). Despite its cytotoxic effect, TMZ also induces cell cycle arrest that may lead to the development of chemoresistance and eventual tumor recurrence. Caffeine, a widely consumed neurostimulan...

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Detaylı Bibliyografya
Yayımlandı:Biomed Res Int
Asıl Yazarlar: Li, Ning, Zhang, Pingde, Kiang, Karrie Mei Yee, Cheng, Yin Stephen, Leung, Gilberto Ka Kit
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Hindawi 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046144/
https://ncbi.nlm.nih.gov/pubmed/30050935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/5364973
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