Lovastatin Enhances Cytotoxicity of Temozolomide via Impairing Autophagic Flux in Glioblastoma Cells

Drug resistance to temozolomide (TMZ) contributes to the majority of tumor recurrence and treatment failure in patients with glioblastoma multiforme (GBM). Autophagy has been reported to play a role in chemoresistance in various types of cancer, including GBM. The anticancer effect of statins is aro...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Zhu, Zhiyuan, Zhang, Pingde, Li, Ning, Kiang, Karrie Mei Yee, Cheng, Stephen Yin, Wong, Vincent Kam-Wai, Leung, Gilberto Ka-Kit
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778891/
https://ncbi.nlm.nih.gov/pubmed/31662972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/2710693
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