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Inhibition of DNA Methylation at the MLH1 Promoter Region Using Pyrrole–Imidazole Polyamide
[Image: see text] Aberrant DNA methylation causes major epigenetic changes and has been implicated in cancer following the inactivation of tumor suppressor genes by hypermethylation of promoter CpG islands. Although methylated DNA regions can be randomly demethylated by 5-azacytidine and 5-aza-2′-de...
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| Publicat a: | ACS Omega |
|---|---|
| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American
Chemical
Society
2016
|
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6044701/ https://ncbi.nlm.nih.gov/pubmed/30023504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.6b00229 |
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