Pyrrole-imidazole polyamide targeted to break fusion sites in TMPRSS2 and ERG gene fusion represses prostate tumor growth

Aberrant overexpression of ERG induced by the TMPRSS2-ERG gene fusion is likely involved in the development of prostate cancer. Synthetic pyrrole–imidazole (PI) polyamides recognize and attach to the minor groove of DNA with high affinity and specificity. In the present study, we designed a PI polya...

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Bibliographic Details
Published in:Cancer Sci
Main Authors: Obinata, Daisuke, Ito, Akiko, Fujiwara, Kyoko, Takayama, Ken-Ichi, Ashikari, Daisaku, Murata, Yasutaka, Yamaguchi, Kenya, Urano, Tomohiko, Fujimura, Tetsuya, Fukuda, Noboru, Soma, Masayoshi, Watanabe, Takayoshi, Nagase, Hiroki, Inoue, Satoshi, Takahashi, Satoru
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462350/
https://ncbi.nlm.nih.gov/pubmed/25088707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12493
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