Pyrrole-imidazole polyamide targeted to break fusion sites in TMPRSS2 and ERG gene fusion represses prostate tumor growth

Aberrant overexpression of ERG induced by the TMPRSS2-ERG gene fusion is likely involved in the development of prostate cancer. Synthetic pyrrole–imidazole (PI) polyamides recognize and attach to the minor groove of DNA with high affinity and specificity. In the present study, we designed a PI polya...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Obinata, Daisuke, Ito, Akiko, Fujiwara, Kyoko, Takayama, Ken-Ichi, Ashikari, Daisaku, Murata, Yasutaka, Yamaguchi, Kenya, Urano, Tomohiko, Fujimura, Tetsuya, Fukuda, Noboru, Soma, Masayoshi, Watanabe, Takayoshi, Nagase, Hiroki, Inoue, Satoshi, Takahashi, Satoru
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462350/
https://ncbi.nlm.nih.gov/pubmed/25088707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12493
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