Inhibition of DNA Methylation at the MLH1 Promoter Region Using Pyrrole–Imidazole Polyamide

[Image: see text] Aberrant DNA methylation causes major epigenetic changes and has been implicated in cancer following the inactivation of tumor suppressor genes by hypermethylation of promoter CpG islands. Although methylated DNA regions can be randomly demethylated by 5-azacytidine and 5-aza-2′-de...

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Опубликовано в: :ACS Omega
Главные авторы: Shinohara, Ken-ichi, Yoda, Natsumi, Takane, Kiyoko, Watanabe, Takayoshi, Fukuyo, Masaki, Fujiwara, Kyoko, Kita, Kazuko, Nagase, Hiroki, Nemoto, Tetsuhiro, Kaneda, Atsushi
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2016
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044701/
https://ncbi.nlm.nih.gov/pubmed/30023504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.6b00229
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