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Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4
Many poly-ubiquitinated proteins are extracted from membranes or complexes by a conserved ATPase, called Cdc48 in yeast and p97/VCP in mammals, before proteasomal degradation(1). Each Cdc48 hexamer contains two stacked ATPase rings (D1 and D2) and six N-terminal (N) domains(2). Cdc48 binds various c...
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| Veröffentlicht in: | Nat Struct Mol Biol |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6044470/ https://ncbi.nlm.nih.gov/pubmed/29967539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0085-x |
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